I can't think of any single issue that I gave up completely upon.

As for series, Starman is my prime instance.

For years, I'd heard on various forum boards about how great and utterly fabulous this series was. So I bought the first Omnibus volume and read the entire book. Harris' art was interesting, lent a distinctive visual look to the book. Jack's strained relationship with his father and his late brother, the O'Dare family and their history, I was most intrigued by the unusual mentor role of the Shade however.

Yet I came away thinking that it was rather good but nothing earth-shattering, certainly not to the high levels of praise that I had read previously. It just didn't grab/interest me enough to warrant reading the rest of the series. That first volume sat on my bookshelf for quite a number of years till I moved recently and I put it into my stack of trades to donate to my local library.